Outcomes and Prognostic Assessment of Post-Transplant Lymphoproliferative Disorder: 20-Year Experience

Hira Shaikh; Zulfa Omer; Koffi Wima; Tara Magge; Shimul A. Shah; Tahir Latif

doi:10.3390/lymphatics3010005

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Outcomes and Prognostic Assessment of Post-Transplant Lymphoproliferative Disorder: 20-Year Experience

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Outcomes and Prognostic Assessment of Post-Transplant Lymphoproliferative Disorder: 20-Year Experience

Hira Shaikh, Zulfa Omer, Koffi Wima, Tara Magge, Shimul A. Shah and Tahir Latif

Lymphatics, Vol.3(1), 5

02/12/2025

DOI: 10.3390/lymphatics3010005

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Abstract

Post-transplant lymphoproliferative disorder (PTLD) is the most common malignancy in adults who receive solid organ transplantation (SOT), apart from skin cancer. It is a serious and potentially fatal complication of chronic immunosuppression (ISI) in SOT recipients. This report describes a 20-year (2001–2021) clinicopathological experience with 59 PTLD patients at an urban center. The median time from transplant to PTLD was 8.5 years and the most common types of transplants were kidney (41%) and liver (31%). Epstein–Barr encoding region (EBER) was positive in 51% tumors, and 50% patients had Epstein–Barr virus (EBV) viremia at diagnosis. Overall survival (OS) at 1 year and 5 years was 78% and 64%, respectively. OS was significantly (p < 0.05) shorter in males (hazard ratio [HR] 3.7), certain organ transplants (lung HR 10.4; liver HR 3.9 relative to kidney), PTLD diagnosed within 12 months of transplant (HR 4.1), multi-organ involvement at diagnosis (HR 7.1), vitamin D deficiency at diagnosis (HR 4.5), and low serum albumin level at diagnosis (HR 3.6). Our study highlights the prognostic factors of PTLD and corroborates improved PTLD outcomes in the past 20 years.

Details

Title: Subtitle: Outcomes and Prognostic Assessment of Post-Transplant Lymphoproliferative Disorder: 20-Year Experience
Creators: Hira Shaikh - University of Iowa Health Care
Zulfa Omer - University of Cincinnati
Koffi Wima - University of Cincinnati
Tara Magge - University of Pittsburgh
Shimul A. Shah - University of Cincinnati
Tahir Latif - University of Cincinnati
Resource Type: Journal article
Publication Details: Lymphatics, Vol.3(1), 5
DOI: 10.3390/lymphatics3010005
ISSN: 2813-3307
eISSN: 2813-3307
Publisher: MDPI
Language: English
Date published: 02/12/2025
Academic Unit: Internal Medicine
Record Identifier: 9984790991702771

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