Journal article
Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer
International journal of gastrointestinal cancer, Vol.32(2-3), pp.125-128
2002
DOI: 10.1385/ijgc:32:2-3:125
PMID: 12794248
Abstract
This is a phase II study of perillyl alcohol in the treatment of patients with metastatic colorectal carcinoma. The primary endpoint is time to progression. Secondary objectives are to evaluate objective response rate and toxicity.
Eligible patients had metastatic adenocarcinoma of the colon or rectum. Patients received perillyl alcohol orally at a dose of 1200 mg/m2. Dose escalation to 1,600 mg/m2 was allowed.
Twenty-seven patients were enrolled. The median time to progression was 1.8 months (range 1 to 3 mo). Four patients received less than one cycle and were not evaluable for response. Of the remaining 23, all had progressive disease. There were no complete or partial responses. Toxicity was relatively mild, with fatigue, nausea and anemia predominating. Three patients withdrew from therapy for toxicity (grade 3 belching, bloating; grade 2 nausea, fatigue, vomiting, anorexia and increase perspiration; grade 1 anorexia).
Despite preclinical evidence of anticancer activity, oral perillyl alcohol administered at this dose and formulation does not appear to have clinical antitumor activity when used for patients with advanced colorectal carcinoma.
Details
- Title: Subtitle
- Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer
- Creators
- Sherry Morgan Meadows - University of Wisconsin–MadisonDaniel MulkerinJordan BerlinHoward BaileyJill KolesarDeb WarrenJames P Thomas
- Resource Type
- Journal article
- Publication Details
- International journal of gastrointestinal cancer, Vol.32(2-3), pp.125-128
- DOI
- 10.1385/ijgc:32:2-3:125
- PMID
- 12794248
- ISSN
- 1537-3649
- eISSN
- 1559-0739
- Grant note
- CA80187-02 / NCI NIH HHS
- Language
- English
- Date published
- 2002
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695788802771
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