Journal article
Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants
ACS applied bio materials, Vol.7(5), pp.3124-3135
04/07/2024
DOI: 10.1021/acsabm.4c00156
PMCID: PMC11110053
PMID: 38584364
Appears in UI Libraries Support Open Access
Abstract
The durability of photografted zwitterionic hydrogel coatings on cochlear implant biomaterials was examined to determine the viability of these antifouling surfaces during insertion and long-term implant usage. Tribometry was used to determine the effect of zwitterionic coatings on the lubricity of surfaces with varying hydration levels, applied normal force, and time frame. Additionally, flexural resistance was investigated using mandrel bending. Ex vivo durability was assessed by determining the coefficient of friction between tissues and treated surfaces. Furthermore, cochlear implantation force was measured using cadaveric human cochleae. Hydrated zwitterionic hydrogel coatings reduced frictional resistance approximately 20-fold compared to uncoated PDMS, which led to significantly lower mean force experienced by coated cochlear implants during insertion compared to uncoated systems. Under flexural force, zwitterionic films resisted failure for up to 60 min of desiccation. The large increase in lubricity was maintained for 20 h under continual force while hydrated. For loosely cross-linked systems, films remained stable and lubricious even after rehydration following complete drying. All coatings remained hydrated and functional under frictional force for at least 30 min in ambient conditions allowing drying, with lower cross-link densities showing the greatest longevity. Moreover, photografted zwitterionic hydrogel samples showed no evidence of degradation and nearly identical lubricity before and after implantation. This work demonstrates that photografted zwitterionic hydrogel coatings are sufficiently durable to maintain viability before, during, and after implantation. Mechanical properties, including greatly increased lubricity, are preserved after complete drying and rehydration for various applied forces. Additionally, this significantly enhanced lubricity translates to significantly decreased force during insertion of implants which should result in less trauma and scarring.
Details
- Title: Subtitle
- Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants
- Creators
- Adreann Peel - University of IowaDouglas Bennion - University of IowaRyan Horne - University of IowaMarlan R Hansen - University of IowaC Allan Guymon - University of Iowa
- Resource Type
- Journal article
- Publication Details
- ACS applied bio materials, Vol.7(5), pp.3124-3135
- Publisher
- American Chemical Society
- DOI
- 10.1021/acsabm.4c00156
- PMID
- 38584364
- PMCID
- PMC11110053
- eISSN
- 2576-6422
- Grant note
- DOI: 10.13039/100005380, name: American Neurotology Society; DOI: 10.13039/100000002, name: National Institutes of Health, award: F30DC019274, R01DC012578, T32DC000040
- Language
- English
- Electronic publication date
- 04/07/2024
- Academic Unit
- Molecular Physiology and Biophysics; Chemical and Biochemical Engineering; Neurosurgery; Otolaryngology
- Record Identifier
- 9984584908402771
Metrics
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