Prefrontal and executive attention network lesions and the development of attention-deficit/hyperactivity symptomatology

Jeffrey E Max; Facundo F Manes; Brigitte A M Robertson; Katherine Mathews; Peter T Fox; Jack Lancaster

doi:10.1097/01.chi.0000156661.38576.0f

Back

Prefrontal and executive attention network lesions and the development of attention-deficit/hyperactivity symptomatology

Journal article

Peer reviewed

Prefrontal and executive attention network lesions and the development of attention-deficit/hyperactivity symptomatology

Jeffrey E Max, Facundo F Manes, Brigitte A M Robertson, Katherine Mathews, Peter T Fox and Jack Lancaster

Journal of the American Academy of Child and Adolescent Psychiatry, Vol.44(5), pp.443-450

05/2005

DOI: 10.1097/01.chi.0000156661.38576.0f

PMID: 15843766

View Online

Abstract

To investigate the association between focal stroke lesions of Posner's executive attention network and a specific region of interest in the frontal lobes (orbital frontal and mesial frontal) and either attention-deficit/hyperactivity disorder (ADHD) or traits of the disorder (ADHD symptomatology). Twenty-nine children with focal stroke lesions were studied with standardized psychiatric assessments and anatomical brain magnetic resonance imaging. The pattern of lesion overlap in subjects with ADHD symptomatology was determined. Fifteen of 28 subjects with no prestroke ADHD were diagnosed with ADHD symptomatology at the time of assessment. The extent of lesions within the executive attention network was marginally related to ADHD symptomatology (p = .088; effect size = 0.66), whereas the extent of lesions in the specific frontal region of interest was significantly related to ADHD symptomatology (p = .040; effect size = 0.82). Lesions within Posner's executive attention network and its orbital frontal connections may be linked to important mechanisms in the expression of ADHD symptomatology after childhood stroke. These findings are consistent with functional and structural imaging findings in studies of idiopathic ADHD.

Attention Deficit Disorder with Hyperactivity - physiopathology

Humans

Prefrontal Cortex - physiopathology

Male

Prefrontal Cortex - pathology

Cognition Disorders - diagnosis

Magnetic Resonance Imaging

Cognition Disorders - etiology

Attention Deficit Disorder with Hyperactivity - complications

Female

Attention Deficit Disorder with Hyperactivity - diagnosis

Child

Nerve Net - physiopathology

Details

Title: Subtitle: Prefrontal and executive attention network lesions and the development of attention-deficit/hyperactivity symptomatology
Creators: Jeffrey E Max - University of California, Children's Hospital and Health Center, San Diego, CA 92123, USA. jmax@ucsd.edu
Facundo F Manes
Brigitte A M Robertson
Katherine Mathews
Peter T Fox
Jack Lancaster
Resource Type: Journal article
Publication Details: Journal of the American Academy of Child and Adolescent Psychiatry, Vol.44(5), pp.443-450
DOI: 10.1097/01.chi.0000156661.38576.0f
PMID: 15843766
NLM abbreviation: J Am Acad Child Adolesc Psychiatry
ISSN: 0890-8567
eISSN: 1527-5418
Publisher: Elsevier Inc; United States
Grant note: P02 MH52176-07 / NIMH NIH HHS K-08 MH 01800-05 / NIMH NIH HHS
Language: English
Date published: 05/2005
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984020750402771

Metrics

16 Record Views

37 Times Cited - Web of Science