Journal article
Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
Nature communications, Vol.11(1), pp.2053-2053
04/28/2020
DOI: 10.1038/s41467-020-15928-z
PMCID: PMC7188806
PMID: 32345979
Abstract
Goal-directed behavior requires the representation of a task-set that defines the task-relevance of stimuli and guides stimulus-action mappings. Past experience provides one source of knowledge about likely task demands in the present, with learning enabling future predictions about anticipated demands. We examine whether spatial contexts serve to cue retrieval of associated task demands (e.g., context A and B probabilistically cue retrieval of task demands X and Y, respectively), and the role of the hippocampus and dorsolateral prefrontal cortex (dlPFC) in mediating such retrieval. Using 3D virtual environments, we induce context-task demand probabilistic associations and find that learned associations affect goal-directed behavior. Concurrent fMRI data reveal that, upon entering a context, differences between hippocampal representations of contexts (i.e., neural pattern separability) predict proactive retrieval of the probabilistically dominant associated task demand, which is reinstated in dlPFC. These findings reveal how hippocampal-prefrontal interactions support memory-guided cognitive control and adaptive behavior.
Details
- Title: Subtitle
- Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
- Creators
- Jiefeng Jiang - Department of Psychology, Stanford University, Stanford, CA, 94305, USA. jiefeng.jiang@stanford.eduShao-Fang Wang - Department of Psychology, Stanford University, Stanford, CA, 94305, USAWanjia Guo - Psychology Department, University of Oregon, Eugene, OR, 97401, USACorey Fernandez - Neuroscience Program, Stanford University, Stanford, CA, 94305, USAAnthony D Wagner - Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.11(1), pp.2053-2053
- DOI
- 10.1038/s41467-020-15928-z
- PMID
- 32345979
- PMCID
- PMC7188806
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- England
- Grant note
- F32AG056080 / U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R21AG058111 / U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
- Language
- English
- Date published
- 04/28/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065830302771
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