Journal article
Prevalence of Duchenne and Becker muscular dystrophies in the United States
Pediatrics (Evanston), Vol.135(3), pp.513-521
03/2015
DOI: 10.1542/peds.2014-2044
PMCID: PMC4477633
PMID: 25687144
Abstract
OBJECTIVE:
To estimate prevalence of childhood-onset Duchenne and Becker muscular dystrophies (DBMD) in 6 sites in the United States by race/ethnicity and phenotype (Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]).
METHODS:
In 2002, the Centers for Disease Control and Prevention established the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) to conduct longitudinal, population-based surveillance and research of DBMD in the United States. Six sites conducted active, multiple-source case finding and record abstraction to identify MD STARnet cases born January 1982 to December 2011. We used cross-sectional analyses to estimate prevalence of DBMD per 10 000 boys, ages 5 to 9 years, for 4 quinquennia (1991–1995, 1996–2000, 2001–2005, and 2006–2010) and prevalence per 10 000 male individuals, ages 5 to 24 years, in 2010. Prevalence was also estimated by race/ethnicity and phenotype.
RESULTS:
Overall, 649 cases resided in an MD STARnet site during ≥1 quinquennia. Prevalence estimates per 10 000 boys, ages 5 to 9 years, were 1.93, 2.05, 2.04, and 1.51, respectively, for 1991–1995, 1996–2000, 2001–2005, and 2006–2010. Prevalence tended to be higher for Hispanic individuals than non-Hispanic white or black individuals, and higher for DMD than BMD. In 2010, prevalence of DBMD was 1.38 per 10 000 male individuals, ages 5 to 24 years.
CONCLUSIONS:
We present population-based prevalence estimates for DBMD in 6 US sites. Prevalence differed by race/ethnicity, suggesting potential cultural and socioeconomic influences in the diagnosis of DBMD. Prevalence also was higher for DMD than BMD. Continued longitudinal surveillance will permit us to examine racial/ethnic and socioeconomic differences in treatment and outcomes for MD STARnet cases.
Details
- Title: Subtitle
- Prevalence of Duchenne and Becker muscular dystrophies in the United States
- Creators
- Paul A Romitti - The University of Iowa, Iowa City, Iowa; paul-romitti@uiowa.eduYong Zhu - The University of Iowa, Iowa City, IowaSoman Puzhankara - The University of Iowa, Iowa City, IowaKatherine A James - University of Colorado, Aurora, ColoradoSarah K Nabukera - The University of Iowa, Iowa City, IowaGideon K D Zamba - The University of Iowa, Iowa City, IowaEmma Ciafaloni - University of Rochester, Rochester, New YorkChristopher Cunniff - The University of Arizona, Tucson, ArizonaCharlotte M Druschel - New York State Department of Health, Albany, New York; State University of New York, Albany, Rensselaer, New York; andKatherine D Mathews - The University of Iowa, Iowa City, IowaDennis J Matthews - University of Colorado, Aurora, ColoradoF John Meaney - The University of Arizona, Tucson, ArizonaJennifer G Andrews - The University of Arizona, Tucson, ArizonaKristin M Caspers Conway - The University of Iowa, Iowa City, IowaDeborah J Fox - New York State Department of Health, Albany, New YorkNatalie Street - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMelissa M Adams - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaJulie Bolen - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMD STARnet
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.135(3), pp.513-521
- DOI
- 10.1542/peds.2014-2044
- PMID
- 25687144
- PMCID
- PMC4477633
- NLM abbreviation
- Pediatrics
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Publisher
- American Academy of Pediatrics; United States
- Grant note
- U01DD000831 / NCBDD CDC HHS U01 DD000189 / NCBDD CDC HHS U01 DD001119 / NCBDD CDC HHS U01 DD000831 / NCBDD CDC HHS U01DD000189 / NCBDD CDC HHS
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Neurology; Radiology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics)
- Record Identifier
- 9983995043502771
Metrics
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