Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties

Khaga R Neupane; Geraldine S Ramon; Brock Harvey; Byeong Chun; Surya P Aryal; Abdullah A Masud; J Robert McCorkle; Jill M Kolesar; Peter M Kekenes-Huskey; Christopher I Richards

doi:10.1002/adhm.202301163

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Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties

Journal article

Open access

Peer reviewed

Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties

Khaga R Neupane, Geraldine S Ramon, Brock Harvey, Byeong Chun, Surya P Aryal, Abdullah A Masud, J Robert McCorkle, Jill M Kolesar, Peter M Kekenes-Huskey and Christopher I Richards

Advanced healthcare materials, Vol.12(27), e2301163

10/01/2023

DOI: 10.1002/adhm.202301163

PMCID: PMC11070110

PMID: 37377147

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https://doi.org/10.1002/adhm.202301163View

Published (Version of record) Open Access

Abstract

Tumor-associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral M1-like phenotype in response to external stimuli. A potential therapeutic strategy for treating cancer may be achieved by modulating macrophages from an M2 to an M1-like phenotype with the tumor microenvironment. Here, programmed nanovesicles are generated as an immunomodulatory therapeutic platform with the capability to re-polarize M2 macrophages toward a proinflammatory phenotype. Programmed nanovesicles are engineered from cellular membranes to have specific immunomodulatory properties including the capability to bidirectionally modulate immune cell polarization. These programmed nanovesicles decorated with specific membrane-bound ligands can be targeted toward specific cell types including immune cells. Macrophage-derived vesicles are engineered to enhance immune cell reprogramming toward a proinflammatory phenotype.

Phenotype

Humans

Immunomodulation

Macrophages - metabolism

Neoplasms - metabolism

Tumor Microenvironment

Details

Title: Subtitle: Programming Cell-Derived Vesicles with Enhanced Immunomodulatory Properties
Creators: Khaga R Neupane - University of Kentucky
Geraldine S Ramon - Loyola University Chicago
Brock Harvey - University of Kentucky
Byeong Chun - Loyola University Chicago
Surya P Aryal - University of Kentucky
Abdullah A Masud - University of Kentucky
J Robert McCorkle - University of Kentucky
Jill M Kolesar - University of Kentucky
Peter M Kekenes-Huskey - Loyola University Chicago
Christopher I Richards - University of Kentucky
Resource Type: Journal article
Publication Details: Advanced healthcare materials, Vol.12(27), e2301163
DOI: 10.1002/adhm.202301163
PMID: 37377147
PMCID: PMC11070110
ISSN: 2192-2640
eISSN: 2192-2659
Grant note: R01 GM138837 / NIGMS NIH HHS R35 GM148284 / NIGMS NIH HHS
Language: English
Date published: 10/01/2023
Academic Unit: Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984696543002771

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