Journal article
Putamen Lesions and the development of attention-deficit/hyperactivity symptomatology
Journal of the American Academy of Child and Adolescent Psychiatry, Vol.41(5), pp.563-571
2002
DOI: 10.1097/00004583-200205000-00014
PMID: 12014789
Abstract
Objective: To investigate the association between focal stroke lesions of the putamen and either attention-deficit/hyperactivity disorder or traits of the disorder (ADHD/Traits).
Method: Twenty-five children with focal stroke lesions were studied with standardized psychiatric assessments and anatomic brain magnetic resonance imaging. The pattern of lesion overlap in subjects with ADHD/Traits was determined.
Results: Fifteen of 25 subjects had ADHD/Traits. The densest area of overlapping lesions (n = 7) in subjects with ADHD/Traits included the posterior ventral putamen. The median lesion volume was 9.7 cm3, and the distribution was highly skewed. Lesion volume was not associated with ADHD/Traits. Therefore the following analyses focused on the 13 subjects with lesions < 10 cm3: ADHD/Traits were exhibited in 6/7 subjects with putamen lesionsversus 2/6 with no putamen lesions (Fisherexacttestp= .1). Half (4/8) of the subjects with ADHD/Traits had overlapping lesions encompassing the posterior ventral putamen. None of the 5 subjects without ADHD/Traits had lesions in this empirically derived region of interest (Fisher exact test p = .1).
Conclusions: Lesions within the dopamine-rich ventral putamen, which is part of the ventral or limbic striatum, tended to increase the risk of ADHD/Traits. ADHD/Traits may therefore be a disinhibition syndrome associated with dysfunction in this cortical-striato-thalamocortical loop.
Details
- Title: Subtitle
- Putamen Lesions and the development of attention-deficit/hyperactivity symptomatology
- Creators
- Jeffrey E MAX - University of California, San Diego and Children's Hospital and Health Center, San Diego (CHSD), United StatesPeter T FOX - University of Texas Health Science Center, San Antonio (UTHSCSA), United StatesJack L LANCASTER - University of Texas Health Science Center, San Antonio (UTHSCSA), United StatesPeter KOCHUNOV - University of Texas Health Science Center, San Antonio (UTHSCSA), United StatesKatherine MATHEWS - University of Iowa, Iowa City, United StatesFacundo F MANES - Raul Carrea Institute for Neurological Research-FLENI, Buenos Aires, ArgentinaBrigitte A. M ROBERTSON - University of California, San Diego and Children's Hospital and Health Center, San Diego (CHSD), United StatesStephan ARNDT - University of Iowa, Iowa City, United StatesDonald A ROBIN - San Diego State University, United StatesAmy E LANSING - CHSD, United States
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Child and Adolescent Psychiatry, Vol.41(5), pp.563-571
- DOI
- 10.1097/00004583-200205000-00014
- PMID
- 12014789
- NLM abbreviation
- J Am Acad Child Adolesc Psychiatry
- ISSN
- 0890-8567
- eISSN
- 1527-5418
- Publisher
- Lippincott; Hagerstown, MD
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center; Neurology (Pediatrics)
- Record Identifier
- 9984019008602771
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