Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings

Ryan Horne; Nir Ben-Shlomo; Megan Jensen; Morgan Ellerman; Caleb Escudero; Rong Hua; Douglas Bennion; C Allan Guymon; Marlan R. Hansen

doi:10.1016/j.actbio.2023.05.011

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Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings

Journal article

Open access

Peer reviewed

Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings

Ryan Horne, Nir Ben-Shlomo, Megan Jensen, Morgan Ellerman, Caleb Escudero, Rong Hua, Douglas Bennion, C Allan Guymon and Marlan R. Hansen

Acta biomaterialia, Vol.166, pp.212-223

08/2023

DOI: 10.1016/j.actbio.2023.05.011

PMCID: PMC10330692

PMID: 37187301

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10330692/pdf/nihms-1900682.pdfView

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Abstract

The foreign body response to implanted materials often complicates the functionality of sensitive biomedical devices. For cochlear implants, this response can reduce device performance, battery life and preservation of residual acoustic hearing. As a permanent and passive solution to the foreign body response, this work investigates ultra-low-fouling poly(carboxybetaine methacrylate) (pCBMA) thin film hydrogels that are simultaneously photo-grafted and photo-polymerized onto polydimethylsiloxane (PDMS). The cellular anti-fouling properties of these coatings are robustly maintained even after six-months subcutaneous incubation and over a broad range of cross-linker compositions. On pCBMA-coated PDMS sheets implanted subcutaneously, capsule thickness and inflammation are reduced significantly in comparison to uncoated PDMS or coatings of polymerized poly(ethylene glycol dimethacrylate) (pPEGDMA). Further, capsule thickness is reduced over a wide range of pCBMA cross-linker compositions. On cochlear implant electrode arrays implanted subcutaneously for one year, the coating bridges over the exposed platinum electrodes and dramatically reduces the capsule thickness over the entire implant. Coated cochlear implant electrode arrays could therefore lead to persistent improved performance and reduced risk of residual hearing loss. More generally, the in vivo anti-fibrotic properties of pCBMA coatings also demonstrate potential to mitigate the fibrotic response on a variety of sensing/stimulating implants.

Details

Title: Subtitle: Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings
Creators: Ryan Horne
Nir Ben-Shlomo
Megan Jensen
Morgan Ellerman
Caleb Escudero
Rong Hua
Douglas Bennion
C Allan Guymon
Marlan R. Hansen
Resource Type: Journal article
Publication Details: Acta biomaterialia, Vol.166, pp.212-223
DOI: 10.1016/j.actbio.2023.05.011
PMID: 37187301
PMCID: PMC10330692
NLM abbreviation: Acta Biomater
ISSN: 1742-7061
eISSN: 1878-7568
Language: English
Electronic publication date: 05/13/2023
Date published: 08/2023
Academic Unit: Molecular Physiology and Biophysics; Chemical and Biochemical Engineering; Neurosurgery; Otolaryngology
Record Identifier: 9984413079502771

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