Journal article
Regional gas transport in the heterogeneous lung during oscillatory ventilation
Journal of applied physiology (1985), Vol.121(6), pp.1306-1318
12/01/2016
DOI: 10.1152/japplphysiol.00097.2016
PMCID: PMC5206385
PMID: 27763872
Abstract
Regional ventilation in the injured lung is heterogeneous and frequency dependent, making it difficult to predict how an oscillatory flow waveform at a specified frequency will be distributed throughout the periphery. To predict the impact of mechanical heterogeneity on regional ventilation distribution and gas transport, we developed a computational model of distributed gas flow and CO
elimination during oscillatory ventilation from 0.1 to 30 Hz. The model consists of a three-dimensional airway network of a canine lung, with heterogeneous parenchymal tissues to mimic effects of gravity and injury. Model CO
elimination during single frequency oscillation was validated against previously published experimental data (Venegas JG, Hales CA, Strieder DJ, J Appl Physiol 60: 1025-1030, 1986). Simulations of gas transport demonstrated a critical transition in flow distribution at the resonant frequency, where the reactive components of mechanical impedance due to airway inertia and parenchymal elastance were equal. For frequencies above resonance, the distribution of ventilation became spatially clustered and frequency dependent. These results highlight the importance of oscillatory frequency in managing the regional distribution of ventilation and gas exchange in the heterogeneous lung.
Details
- Title: Subtitle
- Regional gas transport in the heterogeneous lung during oscillatory ventilation
- Creators
- Jacob Herrmann - Department of Biomedical Engineering, University of Iowa, Iowa City, IowaMerryn H Tawhai - Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; andDavid W Kaczka - Department of Radiology, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.121(6), pp.1306-1318
- Publisher
- United States
- DOI
- 10.1152/japplphysiol.00097.2016
- PMID
- 27763872
- PMCID
- PMC5206385
- ISSN
- 1522-1601
- eISSN
- 1522-1601
- Grant note
- name: Medical Technologies Centre of Research Excellence; DOI: 10.13039/100000002, name: HHS | National Institutes of Health (NIH), award: UM1 HL108724; DOI: 10.13039/100000005, name: U.S. Department of Defense (DOD), award: PR151761
- Language
- English
- Date published
- 12/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
- Record Identifier
- 9984007293102771
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