Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS

Arnoldo Santos; Gabriel C Motta-Ribeiro; Nicolas de Prost; Mauro R Tucci; Tyler J Wellman; Marcos F Vidal Melo; Tilo Winkler

doi:10.1038/s41598-024-56565-6

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Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS

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Open access

Peer reviewed

Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS

Arnoldo Santos, Gabriel C Motta-Ribeiro, Nicolas de Prost, Mauro R Tucci, Tyler J Wellman, Marcos F Vidal Melo and Tilo Winkler

Scientific reports, Vol.14(1), pp.5832-10

03/10/2024

DOI: 10.1038/s41598-024-56565-6

PMCID: PMC10925058

PMID: 38461172

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Abstract

Regional pulmonary perfusion (Q) has been investigated using blood volume (F ) imaging as an easier-to-measure surrogate. However, it is unclear if changing pulmonary conditions could affect their relationship. We hypothesized that vascular changes in early acute respiratory distress syndrome (ARDS) affect Q and F differently. Five sheep were anesthetized and received lung protective mechanical ventilation for 20 h while endotoxin was continuously infused. Using dynamic F-FDG and NN Positron Emission Tomography (PET), regional F and Q were analysed in 30 regions of interest (ROIs) and normalized by tissue content (F and Q , respectively). After 20 h, the lung injury showed characteristics of early ARDS, including gas exchange and lung mechanics. PET images of F and Q showed substantial differences between baseline and lung injury. Lung injury caused a significant change in the F -Q relationship compared to baseline (p < 0.001). The best models at baseline and lung injury were F = 0.32 + 0.690Q and F = 1.684Q -0.538Q , respectively. Endotoxine-associated early ARDS changed the relationship between F and Q, shifting from linear to curvilinear. Effects of endotoxin exposure on the vasoactive blood flow regulation were most likely the key factor for this change limiting the quantitative accuracy of F imaging as a surrogate for regional Q.

Animals

Blood Volume

Endotoxins - toxicity

Lung - diagnostic imaging

Lung - physiology

Lung Injury

Perfusion

Respiratory Distress Syndrome - diagnostic imaging

Sheep

Tomography, X-Ray Computed

Details

Title: Subtitle: Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS
Creators: Arnoldo Santos - Harvard University
Gabriel C Motta-Ribeiro - Universidade Federal do Rio de Janeiro
Nicolas de Prost - Harvard University
Mauro R Tucci - Harvard University
Tyler J Wellman - Massachusetts General Hospital
Marcos F Vidal Melo - Columbia University Irving Medical Center
Tilo Winkler - Massachusetts General Hospital
Resource Type: Journal article
Publication Details: Scientific reports, Vol.14(1), pp.5832-10
DOI: 10.1038/s41598-024-56565-6
PMID: 38461172
PMCID: PMC10925058
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: R01 HL121228 / NHLBI NIH HHS R01-HL121228 / NHLBI NIH HHS
Language: English
Date published: 03/10/2024
Academic Unit: Anesthesia
Record Identifier: 9985141864702771

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