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Regional tidal lung strain in mechanically ventilated normal lungs
Journal article   Open access   Peer reviewed

Regional tidal lung strain in mechanically ventilated normal lungs

Luis Felipe Paula, Tyler J Wellman, Tilo Winkler, Peter M Spieth, Andreas Güldner, Jose G Venegas, Marcelo Gama de Abreu, Alysson R Carvalho and Marcos F Vidal Melo
Journal of applied physiology (1985), Vol.121(6), pp.1335-1347
12/01/2016
DOI: 10.1152/japplphysiol.00861.2015
PMCID: PMC5206384
PMID: 27445302
url
https://doi.org/10.1152/japplphysiol.00861.2015View
Published (Version of record) Open Access

Abstract

Parenchymal strain is a key determinant of lung injury produced by mechanical ventilation. However, imaging estimates of volumetric tidal strain (ε = regional tidal volume/reference volume) present substantial conceptual differences in reference volume computation and consideration of tidally recruited lung. We compared current and new methods to estimate tidal volumetric strains with computed tomography, and quantified the effect of tidal volume (V ) and positive end-expiratory pressure (PEEP) on strain estimates. Eight supine pigs were ventilated with V = 6 and 12 ml/kg and PEEP = 0, 6, and 12 cmH O. End-expiratory and end-inspiratory scans were analyzed in eight regions of interest along the ventral-dorsal axis. Regional reference volumes were computed at end-expiration (with/without correction of regional V for intratidal recruitment) and at resting lung volume (PEEP = 0) corrected for intratidal and PEEP-derived recruitment. All strain estimates demonstrated vertical heterogeneity with the largest tidal strains in middependent regions (P < 0.01). Maximal strains for distinct estimates occurred at different lung regions and were differently affected by V -PEEP conditions. Values consistent with lung injury and inflammation were reached regionally, even when global measurements were below critical levels. Strains increased with V and were larger in middependent than in nondependent lung regions. PEEP reduced tidal-strain estimates referenced to end-expiratory lung volumes, although it did not affect strains referenced to resting lung volume. These estimates of tidal strains in normal lungs point to middependent lung regions as those at risk for ventilator-induced lung injury. The different conditions and topography at which maximal strain estimates occur allow for testing the importance of each estimate for lung injury.
 Animals Inflammation - physiopathology Lung - physiology Positive-Pressure Respiration - methods Respiration, Artificial - methods Swine Tidal Volume - physiology Tomography, X-Ray Computed - methods Ventilator-Induced Lung Injury - physiopathology

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