Journal article
Representational integration and differentiation in the human hippocampus following goal-directed navigation
eLife, Vol.12, e80281
02/14/2023
DOI: 10.7554/eLife.80281
PMCID: PMC9928422
PMID: 36786678
Abstract
As we learn, dynamic memory processes build structured knowledge across our experiences. Such knowledge enables the formation of internal models of the world that we use to plan, make decisions, and act. Recent theorizing posits that mnemonic mechanisms of differentiation and integration - which at one level may seem to be at odds - both contribute to the emergence of structured knowledge. We tested this possibility using fMRI as human participants learned to navigate within local and global virtual environments over the course of 3 days. Pattern similarity analyses on entorhinal cortical and hippocampal patterns revealed evidence that differentiation and integration work concurrently to build local and global environmental representations, and that variability in integration relates to differences in navigation efficiency. These results offer new insights into the neural machinery and the underlying mechanisms that translate experiences into structured knowledge that allows us to navigate to achieve goals.
Details
- Title: Subtitle
- Representational integration and differentiation in the human hippocampus following goal-directed navigation
- Creators
- Corey Fernandez - Stanford UniversityJiefeng Jiang - University of IowaShao-Fang Wang - Stanford UniversityHannah Lee Choi - Stanford UniversityAnthony D Wagner - Stanford University
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.12, e80281
- DOI
- 10.7554/eLife.80281
- PMID
- 36786678
- PMCID
- PMC9928422
- NLM abbreviation
- Elife
- eISSN
- 2050-084X
- Grant note
- MAW 2015.0043 / The Marcus and Amalia Wallenberg Foundation
- Language
- English
- Date published
- 02/14/2023
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984366360002771
Metrics
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