Journal article
Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning
Clinical Toxicology, Vol.61(4), pp.223-227
02/08/2023
DOI: 10.1080/15563650.2022.2156880
Abstract
The Extracorporeal Treatments in Poisoning (EXTRIP) Workgroup defined criteria for extracorporeal toxin removal in patients with metformin poisoning. The primary objective of this study was to determine the benefit of extracorporeal toxin removal in patients meeting EXTRIP criteria. The secondary objective was to determine the performance characteristics of the EXTRIP criteria. This was a single-center retrospective analysis of metformin poisoned patients. Inclusion criteria were: suspicion of metformin poisoning with at least one of the following present: lactate concentration >5 mmol/L; pH 0.05). All 56 patients who did not meet EXTRIP criteria, survived (negative predictive value = 100%). The study did not demonstrate a survival benefit for extracorporeal toxin removal in those meeting EXTRIP criteria. In this retrospective analysis, the recommended EXTRIP criteria had a negative predictive value for death of 100%. Further study is needed to evaluate the benefit of extracorporeal toxin removal in patients meeting EXTRIP criteria for metformin poisoning.
Details
- Title: Subtitle
- Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning
- Creators
- Joshua Trebach - University of Iowa, Emergency MedicineSanjay MohanMarlis GnirkeMark K. Su - New York City Department of Health and Mental HygieneSophie GosselinRobert S. Hoffman
- Resource Type
- Journal article
- Publication Details
- Clinical Toxicology, Vol.61(4), pp.223-227
- Publisher
- Taylor & Francis
- DOI
- 10.1080/15563650.2022.2156880
- ISSN
- 1556-3650
- eISSN
- 1556-9519
- Grant note
- name: No potential conflict of interest was reported by the author(s).; DOI: 10.13039/100011287, name: AACT 2021 Toxicology Trainee Research Grant
- Language
- English
- Date published
- 02/08/2023
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984528354402771
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