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Supplementary Data. Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning
Taylor & Francis
02/08/2023
DOI: 10.6084/m9.figshare.22047985.v1
Abstract
The Extracorporeal Treatments in Poisoning (EXTRIP) Workgroup defined criteria for extracorporeal toxin removal in patients with metformin poisoning. The primary objective of this study was to determine the benefit of extracorporeal toxin removal in patients meeting EXTRIP criteria. The secondary objective was to determine the performance characteristics of the EXTRIP criteria. This was a single-center retrospective analysis of metformin poisoned patients. Inclusion criteria were: suspicion of metformin poisoning with at least one of the following present: lactate concentration >5 mmol/L; pH 0.05). All 56 patients who did not meet EXTRIP criteria, survived (negative predictive value = 100%). The study did not demonstrate a survival benefit for extracorporeal toxin removal in those meeting EXTRIP criteria. In this retrospective analysis, the recommended EXTRIP criteria had a negative predictive value for death of 100%. Further study is needed to evaluate the benefit of extracorporeal toxin removal in patients meeting EXTRIP criteria for metformin poisoning.
Details
- Title: Subtitle
- Supplementary Data. Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning
- Creators
- Joshua TrebachSanjay MohanMarlis GnirkeMark K. SuSophie GosselinRobert S. Hoffman
- Resource Type
- Other
- DOI
- 10.6084/m9.figshare.22047985.v1
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 02/08/2023
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984530560302771
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