Journal article
Safety of catheter ablation for atrial fibrillation in patients with cancer: a nationwide cohort study
Postgraduate medicine, Vol.135(6), pp.562-568
08/18/2023
DOI: 10.1080/00325481.2023.2218188
PMID: 37224412
Abstract
Atrial fibrillation (AF) is the most common arrhythmia in patients with cancer, especially breast, gastrointestinal, respiratory, urinary tract, and hematological malignancies. Catheter ablation (CA) is a well-established, safe treatment option in healthy patients; however, literature regarding safety of CA for AF in patients with cancer is limited and confined to single centers.
We aimed to assess the outcomes and peri-procedural safety of CA for AF in patients with certain types of cancer.
The NIS database was queried between 2016 and 2019 to identify primary hospitalizations with AF and CA. Hospitalizations with secondary diagnosis of atrial flutter and other arrhythmias were excluded. Propensity score matching was used to balance the covariates between cancer and non-cancer groups. Logistic regression was used to analyze the association.
During this period, 47,765 CA procedures were identified, out of which 750 (1.6%) hospitalizations had a diagnosis of cancer. After propensity matching, hospitalizations with cancer diagnosis had higher in-hospital mortality (OR 3.0, 95% CI 1.5-6.2, p = 0.001), lower home discharge rates (OR 0.7, 95% CI 0.6-0.9, p < 0.001) as well as other complications such as major bleeding (OR 1.8, 95% CI 1.3-2.7, p = 0.001) and pulmonary embolism (OR 6.1, 95% CI 2.1-17.8, p < 0.001) but not associated with any major cardiac complications (OR 1.2, 95% CI 0.7-1.8, p = 0.53).
Patients with cancer who underwent CA for AF had significantly higher odds of in-hospital mortality, major bleeding, and pulmonary embolism. Further larger prospective observational studies are needed to validate these findings.
Details
- Title: Subtitle
- Safety of catheter ablation for atrial fibrillation in patients with cancer: a nationwide cohort study
- Creators
- Sahith Reddy Thotamgari - Louisiana State University Health Sciences Center ShreveportAakash R. Sheth - University of Pittsburgh Medical CenterHarsh P. Patel - Southern Illinois University School of MedicineHarigopal Sandhyavenu - Louis. A. Weiss Memorial HospitalBhavin Patel - Mayo ClinicUdhayvir S. Grewal - University of IowaMohammad Alfrad Nobel Bhuiyan - Louisiana State University Health Sciences Center-ShreveportSourbha S. Dani - Lahey Hospital & Medical CenterPaari Dominic - University of Iowa, Cardiovascular Medicine
- Resource Type
- Journal article
- Publication Details
- Postgraduate medicine, Vol.135(6), pp.562-568
- Publisher
- Taylor & Francis
- DOI
- 10.1080/00325481.2023.2218188
- PMID
- 37224412
- ISSN
- 0032-5481
- eISSN
- 1941-9260
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: P20GM121307
- Language
- English
- Electronic publication date
- 05/29/2023
- Date published
- 08/18/2023
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984528354502771
Metrics
10 Record Views