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Supplemental Data. Safety of catheter ablation for atrial fibrillation in patients with cancer: a nationwide cohort study
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Supplemental Data. Safety of catheter ablation for atrial fibrillation in patients with cancer: a nationwide cohort study

Sahith Reddy Thotamgari, Aakash R. Sheth, Harsh P. Patel, Harigopal Sandhyavenu, Bhavin Patel, Udhayvir S. Grewal, Mohammad Alfrad Nobel Bhuiyan, Sourbha S. Dani and Paari Dominic
Taylor & Francis
05/29/2023
DOI: 10.6084/m9.figshare.23256516
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https://doi.org/10.6084/m9.figshare.23256516View
Open Access

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Abstract

Atrial fibrillation (AF) is the most common arrhythmia in patients with cancer, especially breast, gastrointestinal, respiratory, urinary tract, and hematological malignancies. Catheter ablation (CA) is a well-established, safe treatment option in healthy patients; however, literature regarding safety of CA for AF in patients with cancer is limited and confined to single centers. We aimed to assess the outcomes and peri-procedural safety of CA for AF in patients with certain types of cancer. The NIS database was queried between 2016 and 2019 to identify primary hospitalizations with AF and CA. Hospitalizations with secondary diagnosis of atrial flutter and other arrhythmias were excluded. Propensity score matching was used to balance the covariates between cancer and non-cancer groups. Logistic regression was used to analyze the association. During this period, 47,765 CA procedures were identified, out of which 750 (1.6%) hospitalizations had a diagnosis of cancer. After propensity matching, hospitalizations with cancer diagnosis had higher in-hospital mortality (OR 3.0, 95% CI 1.5–6.2, p = 0.001), lower home discharge rates (OR 0.7, 95% CI 0.6–0.9, p < 0.001) as well as other complications such as major bleeding (OR 1.8, 95% CI 1.3–2.7, p = 0.001) and pulmonary embolism (OR 6.1, 95% CI 2.1–17.8, p < 0.001) but not associated with any major cardiac complications (OR 1.2, 95% CI 0.7–1.8, p = 0.53). Patients with cancer who underwent CA for AF had significantly higher odds of in-hospital mortality, major bleeding, and pulmonary embolism. Further larger prospective observational studies are needed to validate these findings.
 General Medicine

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