Spatial Heterogeneity of Lung Perfusion Assessed with N-13 PET as a Vascular Biomarker in Chronic Obstructive Pulmonary Disease

Marcos F. Vidal Melo; Tilo Winkler; R. Scott Harris; Guido Musch; Reginald E. Greene; Jose G. Venegas

doi:10.2967/jnumed.109.065185

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Spatial Heterogeneity of Lung Perfusion Assessed with N-13 PET as a Vascular Biomarker in Chronic Obstructive Pulmonary Disease

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Spatial Heterogeneity of Lung Perfusion Assessed with N-13 PET as a Vascular Biomarker in Chronic Obstructive Pulmonary Disease

Marcos F. Vidal Melo, Tilo Winkler, R. Scott Harris, Guido Musch, Reginald E. Greene and Jose G. Venegas

The Journal of nuclear medicine (1978), Vol.51(1), pp.57-65

01/01/2010

DOI: 10.2967/jnumed.109.065185

PMID: 20008987

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Abstract

Although it is known that structural and functional changes in the pulmonary vasculature and parenchyma occur in the progress of chronic obstructive pulmonary disease (COPD), information is limited on early regional perfusion (Q(r))alterations. Methods: We studied 6 patients with mild or moderate COPD and 9 healthy subjects (6 young and 3 age-matched). The PET (NN)-N-13-labeled saline injection method was used to compute images of Q(r) and regional ventilation (V-r). Transmission scans were used to assess regional density. We used the squared coefficient of variation to quantify Q(r) heterogeneity and length-scale analysis to quantify the contribution to total perfusion heterogeneity of regions ranging from less than 12 to more than 108 mm. Results: Perfusion distribution in COPD subjects showed larger Q(r) heterogeneity, higher contribution from large length scales and lower contribution from small length scales, and larger heterogeneity of Q(r) normalized by tissue density than did healthy subjects. Dorsoventral gradients of V-r were present in healthy subjects, with larger ventilation in dependent regions, whereas no gradient was present in COPD. Heterogeneity of ventilation-perfusion ratios was larger in COPD. Conclusion: Q(r) is significantly redistributed in COPD. Q(r) heterogeneity in COPD patients is greater than in healthy subjects, mainly because of the contribution of large lung regions and not because of changes in tissue density or V-r. The assessment of spatial heterogeneity of lung perfusion with (NN)-N-13-saline PET may serve as a vascular biomarker in COPD.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

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Title: Subtitle: Spatial Heterogeneity of Lung Perfusion Assessed with N-13 PET as a Vascular Biomarker in Chronic Obstructive Pulmonary Disease
Creators: Marcos F. Vidal Melo - Massachusetts General Hospital
Tilo Winkler - Harvard University
R. Scott Harris - Massachusetts General Hospital
Guido Musch - Harvard University
Reginald E. Greene - Massachusetts General Hospital
Jose G. Venegas - Harvard University
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.51(1), pp.57-65
DOI: 10.2967/jnumed.109.065185
PMID: 20008987
NLM abbreviation: J Nucl Med
ISSN: 0161-5505
Publisher: Soc Nuclear Medicine Inc
Number of pages: 9
Grant note: R01-HL-086827; HL-068011 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HL086717 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
Language: English
Date published: 01/01/2010
Academic Unit: Anesthesia
Record Identifier: 9985142949002771

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