Stability of a heparin-free 50% ethanol lock solution for central venous catheters

Marcia Pomplun; Jeremy J Johnson; Susan Johnston; Jill M Kolesar

doi:10.1177/1078155207077598

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Stability of a heparin-free 50% ethanol lock solution for central venous catheters

Journal article

Open access

Peer reviewed

Stability of a heparin-free 50% ethanol lock solution for central venous catheters

Marcia Pomplun, Jeremy J Johnson, Susan Johnston and Jill M Kolesar

Journal of oncology pharmacy practice, Vol.13(1), pp.33-37

03/2007

DOI: 10.1177/1078155207077598

PMID: 17621565

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Abstract

To determine the stability of a compounded 50% ethanol solution (v/v) in syringes used for ethanol locks for central venous catheters. Syringes were compounded with 50% ethanol solution (v/v) and were tested for ethanol concentration over a 28 day period. Syringes were stored at room temperature not protected from light and assayed on days 0, 1, 2, 3, 6, 7, 10, 15, 17, 21, and 28. Ethanolic content was determined using gas chromatography/flame ionization detection (GC/ FID) Varian CP-WAX58 (FFAP) CB capillary column. University of Wisconsin Comprehensive Cancer Center. The mean value for all samples over 28 days was found to be 47.08% with a standard deviation of 2.72. Mean ethanol concentrations ranged from 43 to 52% over the 28 day period and did not vary with time. Ethanol is an effective disinfectant against a broad range of micro-organisms, including bacteria and fungi. Retrospective trials have suggested that the efficacy of an ethanol lock solution is superior to systemic antibiotics to treat and/or prevent central line venous infections; however, there is not a commercially available pharmaceutical product and ethanol 50% solutions are currently compounded. These findings suggest that a 50% (v/v) ethanol solution stored in a syringe at room temperature, not protected from light is stable over a 28 day period.

Anti-Infective Agents, Local - chemistry

Catheterization, Central Venous

Chromatography, Gas

Drug Compounding

Drug Packaging

Drug Stability

Drug Storage

Ethanol - chemistry

Flame Ionization

Solutions

Syringes

Details

Title: Subtitle: Stability of a heparin-free 50% ethanol lock solution for central venous catheters
Creators: Marcia Pomplun - University of Wisconsin Carbone Cancer Center
Jeremy J Johnson - University of Wisconsin–Madison
Susan Johnston - UW Health University Hospital
Jill M Kolesar - University of Wisconsin Carbone Cancer Center
Resource Type: Journal article
Publication Details: Journal of oncology pharmacy practice, Vol.13(1), pp.33-37
DOI: 10.1177/1078155207077598
PMID: 17621565
NLM abbreviation: J Oncol Pharm Pract
ISSN: 1078-1552
eISSN: 1477-092X
Language: English
Date published: 03/2007
Academic Unit: Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984695800002771

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