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The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice
Journal article   Open access   Peer reviewed

The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice

Xueshu Li, Joe Jongpyo Lim, Kai Wang, Bhagwat Prasad, Deepak K Bhatt, Julia Yue Cui and Hans-Joachim Lehmler
Environmental toxicology and pharmacology, Vol.92, 103854
05/2022
DOI: 10.1016/j.etap.2022.103854
PMCID: PMC9090986
PMID: 35331926
url
https://www.ncbi.nlm.nih.gov/pmc/articles/9090986View
Open Access

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Abstract

The disposition of toxicants, such as polychlorinated biphenyls (PCBs), in germ-free (GF) vs. conventional (CV) mice has received little attention to date. Here, we investigate PCB levels in three-month-old female CV and GF mice exposed orally daily for 3 days to 0, 6, or 30 mg/kg body weight of the Fox River Mixture (FRM), an environmental PCB mixture. We euthanized animals 24 h after the final dose. PCB profiles in tissues differed from the FRM profile but were similar in tissues across all 4 PCB exposure groups. PCB levels in CV but not GF mice followed the difference in PCB dose. Importantly, PCB levels were higher in CV than GF mice exposed to the same dose. Hepatic cytochrome P450 enzyme or lipid levels did not explain these trends in PCB tissue levels. Thus, toxicity studies with CV and GF animals need to assess the toxicokinetics of the toxicant investigated.
 Disposition Dose-response Hepatic lipid levels PCB congener profiles PCB homologs Similarity coefficient

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