Journal article
The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study
Respiratory physiology & neurobiology, Vol.148(1), pp.57-64
08/25/2005
DOI: 10.1016/j.resp.2005.05.023
PMID: 15994134
Abstract
Recent PET imaging data from bronchoconstricted sheep (
Vidal Melo et al., 2005) showed that
V
˙
/
Q
˙
distributions were bimodal and topographically patchy, but including a substantial heterogeneity at scales <2.2
ml. In this paper, we reanalyze the experimental data to establish the contribution of ventilation (
V
˙
r
) heterogeneity to the bimodality in
V
˙
/
Q
˙
. This analysis demonstrates that the distribution of
V
˙
r
during bronchoconstriction was bimodal with large patches of severe hypoventilation occupying an average of 41% of the imaged lung. The degree of
hypoventilation to these regions was highly correlated with the degree of oxygenation impairment, but was quite variable amongst animals in spite of consistent degrees of mechanical obstruction. Remarkably, those regions were found to be
hyperventilated before methacholine and their degree of
hyperventilation was correlated with their degree of
hypoventilation during bronchoconstriction. These data suggest that improving the uniformity of ventilation at baseline may be a desirable therapeutic target if the risk of severe hypoxemia during asthma attacks is to be minimized and/or the distribution of inhaled pharmaceuticals is to be optimized.
Details
- Title: Subtitle
- The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study
- Creators
- Jose G. Venegas - Massachusetts General HospitalTobias Schroeder - Massachusetts General HospitalScott Harris - Massachusetts General HospitalR. Tilo Winkler - Harvard Medical SchoolMarcos F. Vidal Melo - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Respiratory physiology & neurobiology, Vol.148(1), pp.57-64
- DOI
- 10.1016/j.resp.2005.05.023
- PMID
- 15994134
- NLM abbreviation
- Respir Physiol Neurobiol
- ISSN
- 1569-9048
- eISSN
- 1878-1519
- Publisher
- Elsevier B.V
- Number of pages
- 8
- Language
- English
- Date published
- 08/25/2005
- Academic Unit
- Anesthesia
- Record Identifier
- 9985141865002771
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