Journal article
The molecular genetics of human facioscapulohumeral muscular dystrophy and the myodystrophy mouse model
Current opinion in neurology, Vol.9(5), pp.394-399
10/1996
PMID: 8894417
Abstract
Facioscapulohumeral dystrophy is an autosomal dominant muscular dystrophy, the gene for which is localized to 4q35. It appears to be caused by deletion of tandem repeats that do not contain an expressed sequence. One current hypothesis is that the deletion affects expression of a centromeric gene (not yet identified) through a position effect. The mouse mutant, myodystrophy (myd), is a candidate model for facioscapulohumeral dystrophy. Myd has a progressive muscular dystrophy and maps to a segment of mouse chromosome 8 that is syntenic with human 4q31-4q35.
Details
- Title: Subtitle
- The molecular genetics of human facioscapulohumeral muscular dystrophy and the myodystrophy mouse model
- Creators
- K D Mathews - Department of Pediatrics, University of Iowa, Iowa City 52242, USAK A Mills
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurology, Vol.9(5), pp.394-399
- Publisher
- England
- PMID
- 8894417
- ISSN
- 1350-7540
- eISSN
- 1473-6551
- Language
- English
- Date published
- 10/1996
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020865002771
Metrics
18 Record Views