The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9

Eric M Libell; Noelle C Bowdler; Carrie M Stephan; Miriam Bridget Zimmerman; Amber M Gedlinske; Katherine D Mathews

doi:10.1002/mus.27184

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The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9

Journal article

Peer reviewed

The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9

Eric M Libell, Noelle C Bowdler, Carrie M Stephan, Miriam Bridget Zimmerman, Amber M Gedlinske and Katherine D Mathews

Muscle & nerve, Vol.63(6), pp. 812-817

01/27/2021

DOI: 10.1002/mus.27184

PMCID: PMC9107796

PMID: 33501999

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https://www.ncbi.nlm.nih.gov/pmc/articles/9107796View

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Abstract

Published information about the experiences of pregnancy in limb girdle muscular dystrophy (LGMD) is limited and does not specify LGMD type, limiting utility. We describe the experience and outcomes of pregnancy in a cohort of women with LGMD type R9 (LGMDR. All women 18 y of age or older with a genetic and clinical diagnosis of LGMDR9 who are enrolled in the University of Iowa Wellstone dystroglycanopathy natural history study (clinicaltrials.gov NCT00313677) were invited to complete a questionnaire about their pregnancy experiences, including questions about pregnancy complications, muscle symptoms experienced during pregnancy, and post-partum course. A total of 22 women responded to the survey. Thirteen women reported 26 live births. The majority of pregnancies that resulted in a live birth were uncomplicated (n = 19, 73%), and most infants had no complications (n = 25, 96%). The rates of assisted vaginal delivery (n = 9, 35%) and induction of labor (n = 18, 70%) were both significantly higher than the national average. Almost half of pregnancies (n = 11, 42%) resulted in increased weakness during pregnancy; only one returned to pre-pregnancy baseline. The data presented here suggest that women with LGMDR9 who are considering a pregnancy should be counseled that they might have a higher likelihood of assisted vaginal delivery and could experience progression of weakness. These results are generally consistent with previous reports, but future studies of pregnancy in defined subtypes of LGMD will be required to confirm these findings and determine if risks vary by genotype.

Muscular Dystrophy

Pregnancy

weakness

limb girdle

LGMDR9

Details

Title: Subtitle: The outcomes and experience of pregnancy in limb girdle muscular dystrophy type R9
Creators: Eric M Libell - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Noelle C Bowdler - Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Carrie M Stephan - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Miriam Bridget Zimmerman - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
Amber M Gedlinske - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Katherine D Mathews - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Muscle & nerve, Vol.63(6), pp. 812-817
DOI: 10.1002/mus.27184
PMID: 33501999
PMCID: PMC9107796
NLM abbreviation: Muscle Nerve
ISSN: 0148-639X
eISSN: 1097-4598
Publisher: United States
Grant note: NIH U54 NS053672 / Paul D. Wellstone Muscular Dystrophy Cooperative Research Center P50 NS053672 / NINDS NIH HHS
Language: English
Date published: 01/27/2021
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Obstetrics and Gynecology; Neurology (Pediatrics); Internal Medicine
Record Identifier: 9984070884502771

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