Journal article
Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lung
Respiratory physiology & neurobiology, Vol.165(1), pp.54-60
2009
DOI: 10.1016/j.resp.2008.10.010
PMCID: PMC2637463
PMID: 18996228
Abstract
The effect of high-frequency oscillatory ventilation (HFOV) settings on the distribution of lung volume (
V
L) with changes in mean airway pressure (Paw), frequency (
f
R) and tidal volume (
V
T) remains controversial. We used computer tomographic (CT) imaging to quantify the distribution of
V
L during HFOV compared to static continuous positive airway pressure (CPAP). In anesthetized, supine canines, CT imaging of the entire lung was performed during CPAP and HFOV at Paw of 5, 12.5 and 20
cm
H
2O,
f
R
=
5, 10, 15
Hz. We found small, statistically significant decreases compared with CPAP in total and regional
V
L during HFOV that were greatest at lower
f
R and Paw. Apex and base sub-volumes underwent changes comparable to the lung overall. Increases in
f
R were accompanied by increases in
P
a
O
2
. These finding provide additional insight into the impact of HFOV settings on the distribution of
V
L and suggest that there is low risk of occult regional over-distention during HFOV in normal lungs.
Details
- Title: Subtitle
- Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lung
- Creators
- R. Blaine Easley - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United StatesChristopher T Lancaster - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United StatesMatthew K Fuld - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United StatesJason W Custer - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United StatesDavid N Hager - Department of Medicine, The Johns Hopkins University, Baltimore, MD, United StatesDavid W Kaczka - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United StatesBrett A Simon - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Respiratory physiology & neurobiology, Vol.165(1), pp.54-60
- DOI
- 10.1016/j.resp.2008.10.010
- PMID
- 18996228
- PMCID
- PMC2637463
- NLM abbreviation
- Respir Physiol Neurobiol
- ISSN
- 1569-9048
- eISSN
- 1878-1519
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
- Record Identifier
- 9984006461602771
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