Journal article
Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system
Neuropharmacology, Vol.61(4), pp.730-738
09/01/2011
DOI: 10.1016/j.neuropharm.2011.05.018
PMID: 21645527
Abstract
Transient receptor potential vanilloid 1 (TRPV1) was shown to modulate hippocampal CA1 pyramidal cell synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Synaptic plasticity is the cellular mechanism thought to mediate declarative learning and memory in the hippocampus. Although TRPV1 is involved in modulating hippocampal plasticity, it has yet to be determined how TRPV1 mediates its effects. Using field electrophysiology in hippocampal CA1 stratum radiatum we investigated how TRPV1 agonists modulate LTP, low frequency stimulation-induced LTD, and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced LTD. First we confirmed that TRPV1 agonists induce enhancement of CA1 pyramidal cell LTP in the absence the GABA
A receptor antagonist picrotoxin. Because it was recently determined that TRPV1 mediates a novel form of LTD in CA1 inhibitory GABAergic interneurons, which can disinhibit CA1 pyramidal cells, we used picrotoxin to block the effect of the GABAergic circuitry on CA1 LTP. When using picrotoxin, the TRPV1 agonist-induced enhancement of CA1 LTP was eliminated suggesting that the GABAergic circuitry is required for TRPV1 agonist mediated increases. Regarding LTD, in contrast to previously reported data, we did not see TRPV1 agonist-mediated effect on low frequency-induced stimulus LTD. However, during DHPG-induced LTD, TRPV1 was involved in the acute, but not the long-term depression phase of this plasticity. In summary, our findings support TRPV1 agonist involvement in hippocampal synaptic plasticity, including its enhancement of CA1 LTP. We demonstrate that the enhancement mediated by TRPV1 agonists requires GABA input to pyramidal cells thus providing a mechanism for how TRPV1 agonists modulate hippocampal synaptic plasticity.
► TRPV1 mediates enhancement of CA1 long-term potentiation (LTP) by theta burst. ► TRPV1 enhanced LTP requires GABAergic circuitry as it is blocked by picrotoxin. ► TRPV1 modulates metabotropic glutamate receptor induced long-term depression. ► This study shows TRPV1 involvement in synaptic plasticity and the mechanism.
Details
- Title: Subtitle
- Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system
- Creators
- Douglas Bennion - Brigham Young UniversityTyron Jensen - Brigham Young UniversityCurtis Walther - Brigham Young UniversityJohn Hamblin - Brigham Young UniversityAndrew Wallmann - Brigham Young UniversityJason Couch - Brigham Young UniversityJacob Blickenstaff - Brigham Young UniversityMichael Castle - Brigham Young UniversityLauren Dean - Brigham Young UniversitySam Beckstead - Brigham Young UniversityCollin Merrill - Brigham Young UniversityCasey Muir - Brigham Young UniversityTeresa St. Pierre - Brigham Young UniversityBryan Williams - Brigham Young UniversityStephen Daniel - Brigham Young UniversityJeffrey G. Edwards - Brigham Young University
- Resource Type
- Journal article
- Publication Details
- Neuropharmacology, Vol.61(4), pp.730-738
- DOI
- 10.1016/j.neuropharm.2011.05.018
- PMID
- 21645527
- NLM abbreviation
- Neuropharmacology
- ISSN
- 0028-3908
- eISSN
- 1873-7064
- Publisher
- Elsevier Ltd
- Number of pages
- 9
- Language
- English
- Date published
- 09/01/2011
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984962626302771
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