Journal article
Unexpected doxorubicin-mediated cardiotoxicity in sisters: Possible role of polymorphisms in histamine n-methyl transferase
Journal of oncology pharmacy practice, Vol.19(3), pp.269-272
09/2013
DOI: 10.1177/1078155212461022
PMCID: PMC3998823
PMID: 23154571
Abstract
The anthracycline anticancer agent doxorubicin has long been recognized to induce a dose-limiting cardiotoxicity and may be associated with genes relevant to doxorubicin disposition. Recent reports suggest a role for a number of single nucleotide polymorphisms in anthracycline cardiotoxicity in children. We describe two adult sisters with anthracycline cardiotoxicity that developed after a relatively low dose of doxorubicin. One sister carried the variant genotype for histamine N-ethyl transferase (HNMT, rs17583889) while the other was heterozygous, suggesting a similar role for these genotypes in adults with anthracycline cardiotoxicity. Although this requires further study, these genotypes may be important in the clinical dosing, or use of the liposomal formulation of doxorubicin.
Details
- Title: Subtitle
- Unexpected doxorubicin-mediated cardiotoxicity in sisters: Possible role of polymorphisms in histamine n-methyl transferase
- Creators
- Kamakshi Sachidanandam - University of Wisconsin–MadisonArlene A Gayle - University of Wisconsin–MadisonH Ian Robins - University of Wisconsin Carbone Cancer CenterJill M Kolesar - University of Wisconsin Carbone Cancer Center
- Resource Type
- Journal article
- Publication Details
- Journal of oncology pharmacy practice, Vol.19(3), pp.269-272
- DOI
- 10.1177/1078155212461022
- PMID
- 23154571
- PMCID
- PMC3998823
- ISSN
- 1078-1552
- eISSN
- 1477-092X
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695796202771
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