Journal article
Unshrinking the baby lung to calm the VILI vortex
Critical care (London, England), Vol.26(1), pp.1-14
08/01/2022
DOI: 10.1186/s13054-022-04105-x
PMCID: PMC9357329
PMID: 35934707
Abstract
Abstract A hallmark of ARDS is progressive shrinking of the ‘baby lung,’ now referred to as the ventilator-induced lung injury (VILI) ‘vortex.’ Reducing the risk of the VILI vortex is the goal of current ventilation strategies; unfortunately, this goal has not been achieved nor has mortality been reduced. However, the temporal aspects of a mechanical breath have not been considered. A brief expiration prevents alveolar collapse, and an extended inspiration can recruit the atelectatic lung over hours. Time-controlled adaptive ventilation (TCAV) is a novel ventilator approach to achieve these goals, since it considers many of the temporal aspects of dynamic lung mechanics.
Details
- Title: Subtitle
- Unshrinking the baby lung to calm the VILI vortex
- Creators
- Gary Nieman - SUNY Upstate Medical UniversityMichaela Kollisch-Singule - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstateHarry Ramcharran - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstateJoshua Satalin - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstateSarah Blair - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstateLouis A. Gatto - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstatePenny Andrews - Department of Medicine, University of MarylandAuyon Ghosh - Department of Surgery, SUNY Upstate Medical Center, SUNY UpstateDavid W. Kaczka - University of IowaDonald Gaver - Tulane UniversityJason Bates - University of VermontNader M. Habashi - Department of Medicine, University of Maryland
- Resource Type
- Journal article
- Publication Details
- Critical care (London, England), Vol.26(1), pp.1-14
- DOI
- 10.1186/s13054-022-04105-x
- PMID
- 35934707
- PMCID
- PMC9357329
- NLM abbreviation
- Crit Care
- ISSN
- 1364-8535
- eISSN
- 1466-609X
- Publisher
- BMC
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01HL142702; DOI: 10.13039/100000090, name: Congressionally Directed Medical Research Programs, award: W81XWH-20-1-0696
- Language
- English
- Date published
- 08/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
- Record Identifier
- 9984295954702771
Metrics
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