Journal article
Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl)
Environmental toxicology and pharmacology, Vol.110, 104520
09/2024
DOI: 10.1016/j.etap.2024.104520
PMCID: PMC11377153
PMID: 39067718
Abstract
Elevated airborne PCB levels in older schools are concerning due to their health impacts, including cancer, metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular issues, neurodevelopmental diseases, and diabetes. During a four-week inhalation exposure to PCB52, an air pollutant commonly found in school environments, adolescent rats exhibited notable presence of PCB52 and its hydroxylated forms in their livers, alongside changes in gene expression. Female rats exhibited more pronounced changes in gene expression compared to males, particularly in fatty acid synthesis genes regulated by the transcription factor SREBP1. In vitro studies with human liver cells showed that the hydroxylated metabolite of PCB52, 4-OH-PCB52, but not the parent compound, upregulated genes involved in fatty acid biosynthesis similar to in vivo exposure. These findings highlight the sex-specific effects of PCB52 exposure on livers, particularly in females, suggesting a potential pathway for increased MASLD susceptibility.
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•PCB52 inhalation exposure increases fatty acid synthesis gene transcripts in liver.•Effects of PCB52 exposure on the livers of young rats is sex-specific.•The hydroxylated form of PCB52 is responsible for transcript changes in liver cells.
Details
- Title: Subtitle
- Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl)
- Creators
- Brynn Kyleakin Helm-Kwasny - Molecular Medicine Graduate Program, The University of Iowa, Iowa City, IA, USAAmanda Bullert - University of IowaHui Wang - University of Iowa, Occupational and Environmental HealthMichael S. Chimenti - University of IowaAndrea Adamcakova-Dodd - University of IowaXuefang Jing - University of IowaXueshu Li - University of IowaDavid K. Meyerholz - University of IowaPeter S. Thorne - University of IowaHans-Joachim Lehmler - University of IowaJames A. Ankrum - University of IowaAloysius J. Klingelhutz - Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Environmental toxicology and pharmacology, Vol.110, 104520
- DOI
- 10.1016/j.etap.2024.104520
- PMID
- 39067718
- PMCID
- PMC11377153
- NLM abbreviation
- Environ Toxicol Pharmacol
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- Publisher
- Elsevier B.V
- Grant note
- Lowa Superfund Research Program (NIH): P42 ES013661 Environmental Health Sciences Research Center (NIH): P30 ES005605
This research was supported by the Iowa Superfund Research Program (NIH P42 ES013661) and carried out in laboratory facilities supported by the Environmental Health Sciences Research Center (NIH P30 ES005605) . This content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies listed above.
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Civil and Environmental Engineering; Microbiology and Immunology; Occupational and Environmental Health; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program; Iowa Institute of Human Genetics
- Record Identifier
- 9984687783002771
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