Dataset: Inhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract.

Laura E Dean; Hui Wang; Amanda J Bullert; Andrea Adamcakova-Dodd; Ashutosh K Mangalam; Peter S Thorne; James A Ankrum; Aloysius J Klingelhutz; Hans-Joachim Lehmler

doi:10.25820/data.007431

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Dataset: Inhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract.

Laura E Dean, Hui Wang, Amanda J Bullert, Hui Wang, Andrea Adamcakova-Dodd, Ashutosh K Mangalam, Peter S Thorne, James A Ankrum, Aloysius J Klingelhutz and Hans-Joachim Lehmler

University of Iowa

11/18/2024

DOI: 10.25820/data.007431

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README_Dataset_for_PCB52_Microbiome_Paper18.88 kBDownload View

READMEData creators, funders, abstract, file list and description, methods.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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data_dictionary30.85 kBDownload View

Data DictionaryData dictionary for tabular data files in this dataset.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Substance_Identifiers1.48 kBDownload View

List of identifiers for the substances used in this study.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Data files and documentation are accessible via this link to Globus. Download from Globus via web browser, or Globus app.Open Data Commons Attribution (ODC-By) V1.0

Abstract

This dataset includes the data from a study investigating how PCB52 affects microbial communities depending on the location in the (GI) gastrointestinal tract and the local profiles of PCB52 and its metabolites present in the GI tract following mucociliary clearance and biliary or intestinal excretion. Sprague-Dawley rats were exposed via nose-only inhalation 4 hours per day, 7 days per week, for 4 weeks to either filtered air or PCB52. Differences in the microbiome and levels of PCB52 and its metabolites were characterized throughout the GI tract Network analysis was performed to characterize interactions between individual PCB52 and its metabolites and specific bacterial abundances,

Metabolites

2,2′,5,5′-tetrachlorobiphenyl

PCBs

Polychlorinated biphenyls

Nose-only inhalation

Microbiome

Persistent organic pollutants

Inhalation exposure

Details

Title: Subtitle: Dataset: Inhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract.
Creators: Laura E Dean - University of Iowa, Occupational and Environmental Health
Hui Wang - University of Iowa, Occupational and Environmental Health
Amanda J Bullert - University of Iowa, Occupational and Environmental Health
Hui Wang - University of Iowa, Occupational and Environmental Health
Andrea Adamcakova-Dodd - University of Iowa, Occupational and Environmental Health
Ashutosh K Mangalam - University of Iowa, Iowa Neuroscience Institute
Peter S Thorne - University of Iowa, Civil and Environmental Engineering
James A Ankrum - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
Aloysius J Klingelhutz - University of Iowa, Microbiology and Immunology
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Resource Type: Dataset
DOI: 10.25820/data.007431
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction, R01ES034691, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 03/17/2022–12/31/2023
Date published: 11/18/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Civil and Environmental Engineering; Microbiology and Immunology; Occupational and Environmental Health; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program
Record Identifier: 9984701155802771

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Dataset: Inhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract.

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