Journal article
Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report
Muscle & nerve, Vol.59(4), pp.422-425
04/2019
DOI: 10.1002/mus.26413
PMCID: PMC6417931
PMID: 30636004
Abstract
Patients with Duchenne muscular dystrophy (DMD) exhibit low bone mineral density and increased fracture risk. Because glucocorticoid therapy results in delayed puberty and short stature, it is important to account for delayed skeletal development when interpreting patients' bone mineral density.
Twelve glucocorticoid-treated patients with DMD were evaluated by dual x-ray absorptiometry scans and wrist x-rays to estimate bone density and bone age, respectively. Z-scores were determined on the basis of chronological age. Each patient was assigned a "corrected" birth date that was calculated according to bone age, and a bone-age-corrected z-score was determined.
Z-scores adjusted for chronological age were lower than those adjusted for bone age.
We suggest the use of bone age as an alternative to chronological age for analysis of bone mineral density in glucocorticoid-treated patients with DMD. Additional research is required to determine the optimal method to predict fracture risk in this patient group. Muscle Nerve 59:422-425, 2019.
Details
- Title: Subtitle
- Use of bone age for evaluating bone density in patients with Duchenne muscular dystrophy: A preliminary report
- Creators
- Asma Al-Zougbi - Department of Medicine, University of Iowa, Iowa City, Iowa, USAKatherine D Mathews - Department of Neurology, University of Iowa, Iowa City, Iowa, USAAmal Shibli-Rahhal - Department of Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.59(4), pp.422-425
- Publisher
- United States
- DOI
- 10.1002/mus.26413
- PMID
- 30636004
- PMCID
- PMC6417931
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Grant note
- U54 NS053672 / NINDS NIH HHS T32 HL007121 / NHLBI NIH HHS NIH 5T32HL007121-42 / Abboud Cardiovascular Research Center NIH U54 NS053672 / Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics); Medicine Administration; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984070383202771
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