Use of corticosteroids in a population-based cohort of boys with duchenne and becker muscular dystrophy

Dennis J Matthews; Katherine A James; Lisa A Miller; Shree Pandya; Kimberly A Campbell; Emma Ciafaloni; Katherine D Mathews; Timothy M Miller; Christopher Cunniff; F John Meaney; Charlotte M Druschel; Paul A Romitti; Deborah J Fox; MD STARnet

doi:10.1177/0883073810362762

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Use of corticosteroids in a population-based cohort of boys with duchenne and becker muscular dystrophy

Journal article

Peer reviewed

Use of corticosteroids in a population-based cohort of boys with duchenne and becker muscular dystrophy

Dennis J Matthews, Katherine A James, Lisa A Miller, Shree Pandya, Kimberly A Campbell, Emma Ciafaloni, Katherine D Mathews, Timothy M Miller, Christopher Cunniff, F John Meaney, …

Journal of child neurology, Vol.25(11), pp.1319-1324

11/2010

DOI: 10.1177/0883073810362762

PMCID: PMC5882203

PMID: 20207610

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http://doi.org/10.1177/0883073810362762View

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Abstract

The use of corticosteroids for treatment of Duchenne and Becker muscular dystrophy in clinical practice from 1991 through 2005 was reviewed in a large population-based cohort (MD STARnet) of boys in 4 regional sites and 6 clinics of the United States. Corticosteroid use increased from 20% (11 of 56 individuals) in 1991 to 44% (93 of 218 individuals) in 2005. Average use varied by site and ranged from 15% to 49%. The median age of corticosteroid initiation was 6.9 years (range, 3.7-17.4 years). Dosage and growth information was available for 102 participants and showed a median dose as 0.729 mg/kg for prednisone and 0.831 mg/kg for deflazacort. T. The most common reasons that corticosteroids were discontinued included weight gain, behavioral side effects, and loss of ambulation, resulting in full-time wheelchair use. Substantial variations in clinical practice were identified among study sites.

United States

Adrenal Cortex Hormones - adverse effects

Muscular Dystrophy, Duchenne - drug therapy

Humans

Adolescent

Child, Preschool

Male

Weight Gain - drug effects

Adrenal Cortex Hormones - therapeutic use

Child

Details

Title: Subtitle: Use of corticosteroids in a population-based cohort of boys with duchenne and becker muscular dystrophy
Creators: Dennis J Matthews - Department of Physical Medicine & Rehabilitation, University of Colorado School of Medicine and The Children's Hospital, Denver, CO 80045, USA. matthews.dennis@tchden.org
Katherine A James
Lisa A Miller
Shree Pandya
Kimberly A Campbell
Emma Ciafaloni
Katherine D Mathews
Timothy M Miller - University of Arizona
Christopher Cunniff
F John Meaney
Charlotte M Druschel
Paul A Romitti
Deborah J Fox
MD STARnet
Resource Type: Journal article
Publication Details: Journal of child neurology, Vol.25(11), pp.1319-1324
DOI: 10.1177/0883073810362762
PMID: 20207610
PMCID: PMC5882203
NLM abbreviation: J Child Neurol
ISSN: 0883-0738
eISSN: 1708-8283
Publisher: United States
Grant note: U01 DD000189 / NCBDD CDC HHS U01 DD000187 / NCBDD CDC HHS 5U01DD000187 / NCBDD CDC HHS
Language: English
Date published: 11/2010
Academic Unit: Neurology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics)
Record Identifier: 9983995162602771

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