Journal article
Very early recurrence of anti-phospholipase A 2 receptor-positive membranous nephropathy after transplantation
American journal of transplantation, Vol.12(6), pp.1637-1642
2012
DOI: 10.1111/j.1600-6143.2011.03957.x
Abstract
Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti-Phospholipase A(2) receptor autoantibodies. We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localization of Phospholipase A(2) receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A(2) receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.
Details
- Title: Subtitle
- Very early recurrence of anti-phospholipase A 2 receptor-positive membranous nephropathy after transplantation
- Creators
- C. D BlosserR AyalonR NairC ThomasL. H Beck
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.12(6), pp.1637-1642
- DOI
- 10.1111/j.1600-6143.2011.03957.x
- ISSN
- 1600-6143
- eISSN
- 1600-6143
- Language
- English
- Date published
- 2012
- Academic Unit
- Stead Family Department of Pediatrics; Obstetrics and Gynecology; Internal Medicine
- Record Identifier
- 9983986082302771
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