Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation

Naomi Vather-Wu; Matthew D Krasowski; Katherine D Mathews; Amal Shibli-Rahhal

doi:10.3233/JND-200625

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Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation

Journal article

Peer reviewed

Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation

Naomi Vather-Wu, Matthew D Krasowski, Katherine D Mathews and Amal Shibli-Rahhal

Journal of neuromuscular diseases, Vol.8(4), pp.481-487

04/01/2021

DOI: 10.3233/JND-200625

PMID: 33814459

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Abstract

Expert guidelines recommend annual monitoring of 25-hydroxyvitamin D (25-OHD) and maintaining 25-OHD ≥30 ng/ml in patients with dystrophinopathies. We hypothesized that 25-OHD remains stable and requires less frequent monitoring in patients taking stable maintenance doses of vitamin D. We performed a retrospective cohort study, using the electronic health record to identify 26 patients with dystrophinopathies with a baseline 25-OHD ≥30 ng/mL and at least one additional 25-OHD measurement. These patients had received a stable dose of vitamin D for ≥3 months prior to their baseline 25-OHD measurement and throughout follow-up. The main outcome measured was the mean duration time the subjects spent with a 25-OHD ≥30 ng/mL. Only 19% of patients dropped their 25-OHD to < 30 ng/ml, with a mean time to drop of 33 months and a median nadir 25-OHD of 28 ng/mL. These results suggest that measurement of 25-OHD every 2-2.5 years may be sufficient in patients with a baseline 25-OHD ≥30 ng/mL and who are on a stable maintenance dose of vitamin D. Other patients may require more frequent assessments.

Duchenne muscular dystrophy

Dystrophinopathy

vitamin D

Details

Title: Subtitle: Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation
Creators: Naomi Vather-Wu - Department of Internal Medicine, University of Iowa, Hawkins Drive, Iowa City IA, USA
Matthew D Krasowski - Department of Pathology, University of Iowa, Hawkins Drive, Iowa City IA, USA
Katherine D Mathews - Department of Pediatrics, University of Iowa, Hawkins Drive, Iowa City IA, USA
Amal Shibli-Rahhal - Department of Internal Medicine, University of Iowa, Hawkins Drive, Iowa City IA, USA
Resource Type: Journal article
Publication Details: Journal of neuromuscular diseases, Vol.8(4), pp.481-487
DOI: 10.3233/JND-200625
PMID: 33814459
NLM abbreviation: J Neuromuscul Dis
eISSN: 2214-3602
Publisher: Netherlands
Language: English
Date published: 04/01/2021
Academic Unit: Neurology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Neurology (Pediatrics); Medicine Administration; Internal Medicine
Record Identifier: 9984071993502771

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