Volatile anesthetics and the treatment of severe bronchospasm: a concept of targeted delivery

Jarred R Mondoñedo; John S McNeil; Samir D Amin; Jacob Herrmann; Brett A Simon; David W Kaczka

doi:10.1016/j.ddmod.2014.02.004

Back

Volatile anesthetics and the treatment of severe bronchospasm: a concept of targeted delivery

Journal article

Peer reviewed

Volatile anesthetics and the treatment of severe bronchospasm: a concept of targeted delivery

Jarred R Mondoñedo, John S McNeil, Samir D Amin, Jacob Herrmann, Brett A Simon and David W Kaczka

Drug discovery today. Disease models, Vol.15, pp.43-50

2015

DOI: 10.1016/j.ddmod.2014.02.004

PMCID: PMC4698912

PMID: 26744597

View Online

Abstract

Status asthmaticus (SA) is a severe, refractory form of asthma that can result in rapid respiratory deterioration and death. Treatment of SA with inhaled anesthetics is a potentially life-saving therapy, but remarkably few data are available about its mechanism of action or optimal administration. In this paper, we will review the clinical use of inhaled anesthetics for treatment of SA, the potential mechanisms by which they dilate constricted airways, and the side effects associated with their administration. We will also introduce the concept of ‘targeted’ delivery of these agents to the conducting airways, a process which may maximize their therapeutic effects while minimizing associated systemic side effects. Such a delivery regimen has the potential to define a rapidly translatable treatment paradigm for this life-threatening disorder.

Details

Title: Subtitle: Volatile anesthetics and the treatment of severe bronchospasm: a concept of targeted delivery
Creators: Jarred R Mondoñedo - Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, United States
John S McNeil - Harvard Medical School, Boston, MA, United States
Samir D Amin - Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, United States
Jacob Herrmann - Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA, United States
Brett A Simon - Harvard Medical School, Boston, MA, United States
David W Kaczka - Harvard Medical School, Boston, MA, United States
Resource Type: Journal article
Publication Details: Drug discovery today. Disease models, Vol.15, pp.43-50
DOI: 10.1016/j.ddmod.2014.02.004
PMID: 26744597
PMCID: PMC4698912
NLM abbreviation: Drug Discov Today Dis Models
ISSN: 1740-6757
eISSN: 1740-6757
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: UM1 HL108724
Language: English
Date published: 2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
Record Identifier: 9984007291602771

Metrics

37 Record Views

See more details