Journal article
Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma
American journal of health-system pharmacy, Vol.67(10), pp.793-797
05/15/2010
DOI: 10.2146/ajhp090247
PMID: 20479100
Abstract
Purpose
The pharmacology, pharmacokinetics, clinical efficacy, safety, adverse effects, dosage and administration, and role in therapy of vorinostat in the treatment of cutaneous T-cell lymphoma (CTCL) are reviewed.
Summary
Vorinostat is a novel histone deacetylase (HDAC) inhibitor approved for the treatment of advanced CTCL. Its primary biochemical mechanism is to correct an aberrant balance between acetylated and deacetylated histones, the proteins involved in chromatin structure and organization. Vorinostat is metabolized and excreted following glucuronidation by the uridine diphosphate glucuronosyl-transferase (UGT) enzyme system. Polymorphisms in the gene encoding for this enzyme system, UGT1A1, may be an important predictor of vorinostat toxicity and response levels in individual patients. Vorinostat is not metabolized by and does not inhibit the cytochrome P-450 isoenzyme system, and only two drug interactions have been noted with vorinostat: warfarin and valproic acid or other HDAC inhibitors. In two Phase II studies, patients with CTCL treated with oral vorinostat demonstrated significant reductions in skin lesions and decreased disease progression. The overall response rate was approximately 30%, including one complete response and a time to response of approximately 10 weeks. At the approved 400-mg, once-daily dose, vorinostat was well tolerated, with the most common grade 1 or 2 adverse events being fatigue, nausea, and diarrhea. More-severe toxicities included thrombocytopenia, fatigue, and nausea and occurred in less than 6% of patients.
Conclusion
Vorinostat, a novel HDAC inhibitor, is efficacious and well tolerated in patients with CTCL and is being investigated for its efficacy and safety in other types of cancers and as a part of combination therapy.
Details
- Title: Subtitle
- Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma
- Creators
- Shannon A. Kavanaugh - University of Wisconsin–MadisonLisa A. White - School of Pharmacy, UWJill M. Kolesar - University of Wisconsin Carbone Cancer Center
- Resource Type
- Journal article
- Publication Details
- American journal of health-system pharmacy, Vol.67(10), pp.793-797
- DOI
- 10.2146/ajhp090247
- PMID
- 20479100
- ISSN
- 1079-2082
- eISSN
- 1535-2900
- Language
- English
- Date published
- 05/15/2010
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984696556502771
Metrics
2 Record Views