What can computed tomography and magnetic resonance imaging tell us about ventilation?

Brett A Simon; David W Kaczka; Alexander A Bankier; Grace Parraga

doi:10.1152/japplphysiol.00353.2012

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What can computed tomography and magnetic resonance imaging tell us about ventilation?

Journal article

Open access

Peer reviewed

What can computed tomography and magnetic resonance imaging tell us about ventilation?

Brett A Simon, David W Kaczka, Alexander A Bankier and Grace Parraga

Journal of applied physiology (1985), Vol.113(4), pp.647-657

08/15/2012

DOI: 10.1152/japplphysiol.00353.2012

PMCID: PMC3774257

PMID: 22653989

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Abstract

This review provides a summary of pulmonary functional imaging approaches for determining pulmonary ventilation, with a specific focus on multi-detector x-ray computed tomography and magnetic resonance imaging (MRI). We provide the important functional definitions of pulmonary ventilation typically used in medicine and physiology and discuss the fact that some of the imaging literature describes gas distribution abnormalities in pulmonary disease that may or may not be related to the physiological definition or clinical interpretation of ventilation. We also review the current state-of-the-field in terms of the key physiological questions yet unanswered related to ventilation and gas distribution in lung disease. Current and emerging imaging research methods are described, including their strengths and the challenges that remain to translate these methods to more wide-spread research and clinical use. We also examine how computed tomography and MRI might be used in the future to gain more insight into gas distribution and ventilation abnormalities in pulmonary disease.

Severity of Illness Index

Multidetector Computed Tomography

Predictive Value of Tests

Lung - pathology

Prognosis

Lung Diseases - diagnosis

Patient Positioning

Pulmonary Ventilation

Humans

Breath Holding

Lung - diagnostic imaging

Lung - physiopathology

Lung Diseases - diagnostic imaging

Magnetic Resonance Imaging

Animals

Models, Biological

Lung Diseases - physiopathology

Lung Diseases - pathology

Respiratory Mechanics

Details

Title: Subtitle: What can computed tomography and magnetic resonance imaging tell us about ventilation?
Creators: Brett A Simon - Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
David W Kaczka
Alexander A Bankier
Grace Parraga
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.113(4), pp.647-657
DOI: 10.1152/japplphysiol.00353.2012
PMID: 22653989
PMCID: PMC3774257
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Grant note: MOP 106437 / Canadian Institutes of Health Research HL089227 / NHLBI NIH HHS MOP 97748 / Canadian Institutes of Health Research
Language: English
Date published: 08/15/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
Record Identifier: 9984007158202771

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