Biography and Expertise
To achieve this goal, my research program focuses on three major interconnected themes: i) utilizing transgenic mice expressing MS susceptible and resistant HLA class II molecules (HLA transgenic mice) to understand the mechanisms of disease pathogenesis; ii) to understand the role of gut microbiome and metabolome in the etiopathogenesis of MS; and iii) test therapeutic efficacy of human gut derived bacteria as drug (BRUG) in animal models of MS.
Research
- To understand the role of gut microbiome and metabolome in the etiopathogenesis of MS
- Human gut derived commensal as a pof
- To decipher the mechanism by which HLA class II genes determine susceptibility and resistance to MS
Research interests
- human commensal as therapeutic agent
- Cellular immune response
- immune response
- cytokines
- inflammation
- gut microbiome
- transgenic mice
- HLA
- multiple slcerosis
- Autoimmune diseases
Keywords: Multiple sclerosis, EAE, MHC, HLA transgenic mice, cytokine, gut mcirobiome, human commensal as therapeutic agent